1st Generation Antipsychotic Resource Library

What are 1st Generation Antipsychotics? Also called typical or conventional antipsychotics, these medications were developed starting in the 1950s and work primarily by blocking dopamine D2 receptors in the brain. They are highly effective for psychotic symptoms but carry a higher risk of movement-related side effects (EPS) than newer antipsychotics. They are categorized by potency — high-potency agents have more movement side effects but less sedation, while low-potency agents cause more sedation but fewer movement effects. Despite being older, many remain widely used today due to their proven effectiveness and lower cost.