SNRI Patient Resource Library
Educational handouts for each SNRI medication from Renee Reece, ARNP, PMHNP-BC
What is an SNRI? Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) work by increasing the availability of both serotonin and norepinephrine in the brain. This dual action makes them effective for depression, anxiety, and in some cases chronic pain. They are often chosen when SSRIs have not been fully effective, or when pain, fatigue, or low motivation are prominent symptoms alongside depression. Click any medication below to learn more.
Available Medication Handouts
Medication Education
Duloxetine (Cymbalta)
An SNRI with unique pain-relieving properties. FDA-approved for depression, anxiety, fibromyalgia, neuropathy, and chronic pain.
Depression Anxiety Pain Fibromyalgia
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Medication Education
Venlafaxine (Effexor XR)
One of the most widely prescribed SNRIs. FDA-approved for depression, GAD, social anxiety, and panic disorder.
Depression Anxiety Panic PTSD
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Medication Education
Desvenlafaxine (Pristiq)
The active metabolite of Effexor with simpler once-daily dosing and fewer drug interactions. Great option for depression and anxiety.
Depression Anxiety
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Medication Education
Levomilnacipran (Fetzima)
A unique SNRI that preferentially targets norepinephrine — particularly helpful when fatigue, motivation, and concentration are key concerns.
Depression Fatigue Motivation
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