ADHD Medication Resource Library

Patient education handouts for ADHD medications — stimulant and non-stimulant — from Renee Reece, ARNP, PMHNP-BC

Stimulants vs. Non-Stimulants — ADHD medications fall into two main categories. Stimulants (amphetamines and methylphenidate) work quickly — often within an hour — and are the most effective first-line treatments. Non-stimulants take weeks to reach full effect but are not controlled substances and may be preferred when stimulants are not tolerated, when anxiety or tics are present, or when there is a history of substance misuse. Many patients do best on a combination. Click any medication below to learn more.
Medication Education  ·  Non-Stimulant — Selective NRI

Atomoxetine (Strattera)

The first non-stimulant FDA-approved for ADHD. Not a controlled substance. Steady 24-hour coverage. Particularly useful when ADHD co-occurs with anxiety or substance use history.

ADHD Non-Stimulant Not Controlled 24-Hour
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Medication Education  ·  Non-Stimulant — NRI / Serotonin Modulator

Viloxazine (Qelbree)

A newer non-stimulant with a unique dual norepinephrine and serotonin mechanism. Works faster than atomoxetine. Not a controlled substance.

ADHD Non-Stimulant Newer Option
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Medication Education  ·  Non-Stimulant — Alpha-2A Agonist

Guanfacine ER (Intuniv)

Works directly in the prefrontal cortex to improve impulse control and attention. Especially effective for hyperactivity, aggression, and tics. Can be used alone or with stimulants.

ADHD Non-Stimulant Tics Hyperactivity
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Medication Education  ·  Non-Stimulant — Alpha-2 Agonist

Clonidine ER (Kapvay)

Similar to Intuniv but more sedating. Particularly useful for ADHD-related sleep difficulties, tics, and hyperactivity. Often added to stimulants for enhanced coverage.

ADHD Non-Stimulant Sleep Tics
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Medication Education  ·  Non-Stimulant — NDRI (Off-Label)

Bupropion (Wellbutrin)

The only antidepressant with meaningful ADHD evidence. Treats both ADHD and depression simultaneously. Not a controlled substance. Takes 2–4 weeks for full effect.

ADHD Depression Non-Stimulant Off-Label
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